Searchable abstracts of presentations at key conferences in endocrinology

ea0017oc15 | Diabetes 2 | BSPED2008

Extreme insulin resistance due to an insulin receptor mutation presenting as premature adrenarche evolving to polycystic ovarian syndrome in a non-obese girl

Wei C , Halsall DJ , O'Rahilly S , Semple R , Burren C

We report a non-obese 14-year old white female who initially presented to the paediatric endocrine service aged 7 years with adrenarche. She was born small for gestational age (2nd centile) but was otherwise developmentally normal with no significant past medical history. There was maternal history of polycystic ovarian syndrome (PCOS) but no family history of type 2 diabetes (T2DM). A GnRH test showed a pre-pubertal response and she was discharged after 1 year of follow-up wi...